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In vivo effects of SCR‐7952. (A) Tumor volumes and (B) body weights of HCT116 MTAP −/− tumor‐bearing mice treated with SCR‐7952, AG‐270, or vehicle (mean ± SEM, n = 7). (C) The effect of SCR‐7952 on human UGT1A1 in a biochemical assay. (D) The levels of plasma total bilirubin (TBIL), direct bilirubin (DBIL), and unconjugated bilirubin (UBIL) of mice 2 h after the final dose (mean ± SEM, n = 3). p Values were calculated using two‐way ANOVA. ****p < 0.0001.
