The interactions of compounds CS, CS₁, CS₂ and V58 with EGFR.

Compound	Affinity (kcal mol−1)	Amino acid	Interaction types	Distance (Å)
CS	−6.1	MET 793	Hydrogen bond	3.03
				2.36
		ASP 800	Hydrogen bond	2.45
		CYS 797	van der Waals	—
		PRO 794	van der Waals	—
		GLY 796	Carbon hydrogen bond	—
CS1	−8	LYS 716	Pi–cation	3.92
		LEU 718	Pi–sigma	2.78
		LYS 745	Hydrogen bond	2.84
		PRO 794	Pi–alkyl bonds	5.06
		ARG 841	Hydrogen bond	2.18
CS2	−6.5	CYS 797	Hydrogen bond	3.06
		CYS 797	2Pi–alkyl bonds	4.42
				4.67
		LEU 844	Alkyl bonds	5.14
				5.10
		ASP 800	van der Waals	—
		GLY 796	van der Waals	—
		GLU 804	van der Waals	—
		HIS 805	van der Waals	—
V58	−9.9	VAL 726	Two Pi–alkyl bonds	3.93
				4.52
		LYS 728	Pi–alkyl bonds	4.74
		ALA 743	Pi–alkyl bond	3.98
		LYS 745	Pi–alkyl bond	4.36
		MET 790	Pi–sulfur	3,91
		MET 793	Hydrogen bond	2.17
				2.76
		LEU 844	Pi–alkyl bond	4.43
		THR 854	Hydrogen bond	2.37