Skip to main content
. 2024 Sep 6;12:1434269. doi: 10.3389/fcell.2024.1434269

FIGURE 7.

FIGURE 7

Sera from NOD.B10 males shows enriched reactivity for ANA-specific IgM autoantigens as compared to sex-matched Tlr7-deficient mice. Sera from NOD.B10 males and females, and NOD.B10 Tlr7+/ , NOD.B10 Tlr7−/− , and NOD.B10 Tlr7-/y mice were harvested (n = 6 each) and autoantigen arrays were performed. (A) Normalized net signal intensity values for IgM and IgG autoantibodies differentially expressed in a sex-biased manner are shown. Horizontal lines represent mean and SEM (*adj p-value < 0.1, **adj p-value < 0.05, ***adj p-value < 0.01 for the hypothesis tests described in the statistical section). (B) Heatmaps showing ANA-specific IgM are shown for female (left panel) and male mice (middle panel). Autoantibodies that are enriched in male NOD.B10 mice as compared to NOD.B10 Tlr7-/y mice are shown (right panel). (C) Heatmaps illustrating ANA-specific IgG reactivity are shown for female (left panel) and male mice (right panel).