Figure 5.
mRNA nanoparticles targeting T cells. (A) Schematic illustration of various receptors expressed on T cells that could be employed to design T cells-targeted NP-mediated delivery systems; (B) Schematic diagram of the preparation of mCherry mRNA for targeted delivery to T cells using αCD3 F(ab')2. Adapted with permission from 69, copyright 2022 Elsevier; (C) Schematic diagram of targeted delivery of mRNA to CD4+ T cells. Adapted with permission from 70; (D) Schematic representation of delivery of FAP CAR mRNA using CD5-targeted LNPs. Adapted with permission from 71, copyright 2022 American Association for the Advancement of Science; (E) Schematic representation of delivery disease-specific CAR or TCR transiently expressed nucleic acid (IVT mRNA) using CD8-targeted nanoparticles. Adapted with permission from 72, copyright 2020 Springer Nature; (F) Schematic illustration of enhanced tumor immunotherapy via phospholipid nanoparticles (PL1) delivery of OX40 mRNA combined with anti-OX40 antibodies. Adapted with permission from 73, copyright 2021 Springer Nature.