Figure 9.
mRNA nanoparticles targeting neutrophils. (A) Schematic illustration of various receptors expressed on neutrophils that could be employed to design neutrophils-targeted NP-mediated delivery systems; (B) After intratumoral injection of 5 μg of mRNA encoding OX40L, OX40L mRNA can be delivered to a variety of bone marrow cells, including granulocytes. Adapted with permission from 31, copyright 2019 The American Association for the Advancement of Science; (C) Schematic diagram of the synthesis of lipid nanoparticles containing mRNA and the expression of Cre mRNA in various immune cells including neutrophils. Adapted with permission from 79, copyright 2017 American Chemical Society.