Table 1.

The application of mRNA

Application	Agent	Disease/Condition	Reference
Protein replacement therapy	PTEN mRNA	subcutaneous PTEN-mutated melanoma and orthotopic PTEN -null prostate tumor models	6
	KDM6A mRNA	bladder cancer	7
	TP53 mRNA	hepatocellular carcinoma and non-small-cell lung cancer	8
Gene editing	Cas9 mRNA	Lung-, spleen- and liver-targeted selective organ targeting (SORT) lipid nanoparticles	9
	mRNA/single-guide RNA	tissue-selective mRNA delivery and CRISPR-Cas9 gene editing in spleen, liver and lungs.	10