Table 5.
Current clinical trials of mRNA-nanoparticle therapy against cancer.
| Cancer type | mRNA | Nanoparticle carrier | Phase | NCT number | Reference |
|---|---|---|---|---|---|
| Metastatic non-small cell lung cancer | BI 1361849 | LNPs | I/II | NCT03164772 | https://clinicaltrials.gov/ct2/show/NCT03164772 |
| Malignant solid tumors | BNT113 | Liposomes | II | NCT04534205 | https://clinicaltrials.gov/ct2/show/NCT04534205 |
| Squamous cell carcinoma, head and neck neoplasm, cervical neoplasm, penile neoplasms malignant | HARE-40 | LNPs | I/II | NCT03418480 | https://clinicaltrials.gov/ct2/show/NCT03418480 |
| Melanoma | Lipo-MERIT | LNPs | I | NCT02410733 | https://clinicaltrials.gov/ct2/show/NCT02410733 |
| Melanoma, colon cancer, gastrointestinal cancer, genitourinary cancer, hepatocellular cancer | mRNA-4650 | LNPs | I/II | NCT03480152 | https://clinicaltrials.gov/ct2/show/NCT03480152 |
| Non-small cell lung cancer, pancreatic neoplasms, colorectal neoplasms | mRNA-5671/V941 | LNPs | I | NCT03948763 | https://clinicaltrials.gov/ct2/show/NCT03948763 |
| Adult glioblastoma | RNA-LPs | Liposomes | I | NCT04573140 | https://clinicaltrials.gov/ct2/show/NCT04573140 |
| Melanoma/colorectal cancer | RO7198457 | LNPs | II | NCT03815058 | https://clinicaltrials.gov/ct2/show/NCT03815058 |
| BNT122 | NCT04486378 | ||||
| Metastatic neoplasm | SAR441000 | LNPs | I | NCT03871348 | https://clinicaltrials.gov/ct2/show/NCT03871348 |
| Triple negative breast cancer | TNBC-MERIT | Liposomes | I | NCT02316457 | https://clinicaltrials.gov/ct2/show/NCT02316457 |
| Ovarian cancer | W_ova1 | Liposomes | I | NCT04163094 | https://clinicaltrials.gov/ct2/show/NCT04163094 |
| Non-small cell lung cancer | CV9202 | Protamine | I/II | NCT03164772 | https://clinicaltrials.gov/ct2/show/NCT03164772 |
| Melanoma/non-small cell lung cancer | mRNA-4157 | LNPs | I/II/III | NCT03897881, NCT03313778 | https://clinicaltrials.gov/ct2/show/NCT03313778 |