Figure 2.

Saturation binding, uptake, and release of lutetium‑177- and copper‑64-labeled TATE variants measured using intact MPC cell monolayers; (A) Total and non-specific binding at radioligand concentrations between 0.3-40 nmol/L (transfer-corrected); (B) Specific binding and effective receptor-mediated uptake at a radioligand concentration of 25 nmol/L; (C) Biphasic release from cells after incubation at a radioligand concentration of 25 nmol/L followed by radioligand removal; cells were incubated with radioligands for 1 hour at 37° C; non-specific binding was determined in presence of 1 µmol/L acetyl-TATE; (A_m) molar activity at incubation start; data presented as means ± standard error; significance of differences compared to [¹⁷⁷Lu]Lu‑DOTA-TATE *** p < 0.001.