Figure 3. Characterization of the metabolome in H460 and H460_met as well as in H460_KO_met and H460_met cells. Volcano plots showing accumulated [log2(FC) on X axis] metabolites that were significantly different [–log10(p-value) on Y axis] between the H460 group and H460_met group in negative (A) and positive (B) ion mode, respectively. Volcano plots showing differential metabolites between the H460_KO_met group and H460_met group in negative (C) and positive (D) ion mode, respectively. The green and red points represent respectively down-regulated and up-regulated metabolites.
