Figure 4.

(A) Modified Racine Score test in mice with M₁ PAMs. Pretreatment with M₁ PAMs (100 mg/kg, i.p., 10 mL/kg, 180 min) BQCA (2), MK-7622 (3), PF-0674427 (4), resulted in robust behavioral convulsions at 3 h post administration, while VU6007496 (11) and VU6006874 (12) did not cause any observed adverse effects. N = 3/group of male C57Bl/6 mice. ANOVA p < 0.0001; ****p < 0.0001 as compared to vehicle control. (B) Time course graph showing that bath application of 3 μM VU6007496 (11) for 20 min led to no significant change in fEPSP slope. N = 8 brain slices from 3 different male C57Bl/6 mice.