Table 1.

Basic characteristics of the study population.

Variables	MTHFR rs1801133 carriers (N=1624)			Non-carriers (n=1879)		P value
	Mean	SD		Mean	SD
Agea	67.42	13.16		67.11	12.89	0.4859
BMIa	24	3.99		23.89	3.93	0.539
	N	%		N	%
Genderb						0.5868
Female	1217	74.94		1423	75.73
Male	407	25.06		456	24.27
Comorbiditiesb
Dementia	63	3.88		69	3.67	0.7482
Stroke	112	6.9		121	6.44	0.5883
Deep vein thrombosis	36	2.22		38	2.02	0.6899
Pulmonary embolism	11	0.68		22	1.17	0.1316
CAD (coronary artery disease)	80	4.93		79	4.2	0.3061
DM (diabetes mellitus)	457	28.14		532	28.31	0.9099
Hypertension	3	0.18		7	0.37	c0.3560
Dyslipidemia	37	2.28		45	2.39	0.82
Hypothyroidism	115	7.08		157	8.36	0.1599
Osteoporosis	871	53.63		928	49.39	0.0122
Major fracture	128	7.88		162	8.62	0.4281
Hip fracture	38	2.34		48	2.55	0.6823
Major Depressive Disorder	0	0		0	0	-
Schizophrenia	1	0.06		1	0.05	c1.00

^aContinuous variables were expressed as mean ± standard deviation (SD) and were analyzed using Student's t-test for normal data distributions

^bCategorical variables were expressed as numbers (percent) and were analyzed using the Chi-square test.

^cCategorical variables were expressed as numbers (percent) and were analyzed using the Fisher's exact probability test.