Table 3.

Herpes zoster risk stratified by sex in different age subgroups.

	Cases occurring new-onset herpes zoster
Subgroups	Total knee replacement cohort (No. of event/ Total knee replacement patient amount in each subgroup)	Control cohort (No. of event/ non-total knee replacement patient amount in each subgroup)	HR (95% CI)a,b
50-64 years old
Male	19/2517	23/2517	0.829 (0.452,1.522)
Female	59/3590	38/3590	1.543 (1.026,2.320)
≥ 65 years old
Male	165/14699	144/14699	1.111 (0.889,1.389)
Female	419/23559	352/23559	1.162 (1.008,1.339)

^a Propensity score matching was performed on age at index, sex, race, body mass index, lab data, status of comorbidities, lifestyle, socioeconomic issues, medical utilization status, vaccination for herpes zoster status.

^b Follow-up time in all analyses in this table was set as 5-years, starting from 90 days after index date