Figure 4.

Intravitreal (IVT) delivery of ADI-PEG20 and/or Anti-VEGF improves blood-retinal barrier function and visual function in db/db mice. Representative western blots and quantitation of extravasated albumin (A, B) in retinas from mice injected IVT with ADI-PEG20, Anti-VEGF, their combination (Comb) or vehicle (PBS). Quantification is expressed as fold change from Db/+ controls (n = 9–10/group). Visual acuity and contrast threshold (C–F) for mice that received IVT treatment with anti-VEGF, ADI-PEG20, or their combination (Comb.) in one eye and PBS vehicle control in the other 7 (C, D) and 14 (E, F) days after IVT injections (n = 9–10/group). ∗p < 0.05, ∗∗p < 0.01.