Figure 5.

Systemic ADI-PEG20 treatment improves visual functions in db/db mice. Visual acuity (A, C), measured as spatial frequency threshold, was determined every two weeks in the intraperitoneal (IP) 4-week and intramuscular (IM) 12-week studies (n = 9–10/group for both). Contrast sensitivity (B, D), measured as contrast threshold, was also determined every two weeks in the 4- and 12-week studies (n = 9–10/group for both). ns = not significant, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001.