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. 2024 Aug 29;89:102020. doi: 10.1016/j.molmet.2024.102020

Figure 6.

Figure 6

Treatment with ADI-PEG20 improves heat sensitivity and wound closure. Paw withdrawal response time to a thermal stimulus was assessed at the end of the 4-week study (A) and every three weeks for the 12-week study (B) (n = 6–7/group for 4-week study, n = 9–10/group for 12-week study). ns = not significant, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001 Wound healing was assessed after 3 weeks of IP treatment. Representative images and quantitation (C, D) of wound closure progress as percentage of baseline wound area at baseline and over 8 days of treatments. (n = 5–8/group). ns = not significant, #p < 0.05 db/db PEG20 vs db/db ADI-PEG20, ∗∗p < 0.01, ∗∗∗p < 0.001 and ∗∗∗p < 0.0001 Db/+PEG20 vs db/db PEG20.