Figure 8.

Effects ofl-Arginine andl-Citrulline treatments on markers of inflammation, oxidative stress and JAK/STAT1 signaling in activated BMDM. Representative western blots and quantitation of iNOS, IL-1β, and TNFα (A,B,C,D) in IFNγ/LPS activated BMDM treated with l-Arginine (120 or 2 μM) or l-citrulline (50 or 500 μM). Representative western blots and quantitation of p-JAK2 and JAK2 (E, F) in IFNγ/LPS activated BMDM after treatments with 50 or 500 μM of l-Citrulline. (n = 3/group). ns = not significant, ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001 and ∗∗∗∗p < 0.0001.