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. 2024 Aug 27;27(9):110828. doi: 10.1016/j.isci.2024.110828

Figure 5.

Figure 5

The effect of P. corporis on bacteria-induced polyQ aggregation and activation of the heat-shock response

(A–C) The effect of co-colonizing intestinal polyQ44 worms with (A) K. pneumoniae HM-751 and P. corporis HM-1294, (B) E. coli OP50 and P. corporis HM-12924, (C) K. pneumoniae HM-751 and E. coli OP50. Data are represented as the average number of aggregates per intestinal polyQ44 worm obtained from three independent experiments for a total of 60 worms. Statistical significance was calculated using one-way analysis of variants (ANOVA) followed by multiple comparison Dunnett’s post-hoc test (∗∗∗∗p < 0.0001).

(D) Nomarski and fluorescent (EGFP) images of transgenic worms expressing transcriptional fusion reporter hsp70p::GFP, fed E. coli OP50, P. corporis HM-1294, K. pneumoniae HM-751, and as a positive control, heat-shocked worms fed E. coli OP50. Scale bar is 200 μm.