Fig. 1.

Identification of macrophage Hmox1 as the key FRG involved in plaque destabilization

A. GO enrichment analysis of DEGs (GSE163154) in terms of BP, CC, and MF. B. Upregulated and downregulated signalling pathways in non-IPH and IPH (GSE163154) samples based on GSEA enrichment analysis. C. Infiltration of 28 types of immune cells in non-IPH and IPH (GSE163154) patients. D. Assessment of Hmox1 expression in macrophages via scRNA-seq datasets. E. Histological analysis of stable and unstable plaques (HE, Masson, and oil red O staining) and immunohistochemistry analysis of Hmox1 expression. GSEA, gene set enrichment analysis; DEGs, differentially expressed genes; BP, biological process; CC, cellular component; MF, molecular function; IPH, intraplaque haemorrhage. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)