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. 2024 Sep 20;10(38):eadj4122. doi: 10.1126/sciadv.adj4122

Fig. 1. SELENOW is up-regulated in muscle with age-related sarcopenia.

Fig. 1.

(A) Relative expression levels of SELENOW in mRNA and protein level of GAS muscle from the GSE159952 database, n = 4. (B and C) Western blot analysis of SELENOW expression in TA, GAS, and QU muscles after DEX treatment, n = 4. (D) Relative expression levels of Fndc5 in mRNA and protein level of GAS muscle from the PMID 35017317 paper, n = 5 to 6. (E) Photographs of young (3-month-old) and aged (24-month-old) mice. (F) Body weights of young and aged mice, n = 12 to 13. (G) Representative hematoxylin and eosin (H&E)–stained cross sections in TA muscle of young and aged mice; scale bars, 100 μm. (H and I) Western blot analysis of protein levels of SELENOW, Atrogin-1, and MuRF-1 in TA muscle of young and aged mice. GAPDH was used as the loading control, n = 4. Data are means ± SEM. Student’s t test, *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001