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. 2024 Sep 20;10(38):eadj4122. doi: 10.1126/sciadv.adj4122

Fig. 2. SELENOW deletion does not affect muscle size or histology.

Fig. 2.

(A) CRISPR-Cas9 gene-targeting strategy for the generation of SELENOW KO mice. (B) Western blot analysis of SELENOW in TA muscles of WT and KO mice, n = 2. (C) Average body weights of mice from 3 to 12 weeks of age, n = 7. (D and E) Gross morphology mass analysis of TA, EDL, GAS, SOL, and QU in WT and KO mice, n = 7. (F) Representative H&E staining and Laminin staining of the myofiber cross section of TA; scale bars, 100 μm. (G and H) Related myofiber cross-sectional area (CSA) and frequency of distribution for CSA of TA muscle, n = 7. Data are means ± SEM; Student’s t test.