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. 2024 Sep 20;10(38):eadj4122. doi: 10.1126/sciadv.adj4122

Fig. 8. Overexpression of SELENOW alleviates muscle atrophy caused by DEX.

Fig. 8.

(A and B) Mass analysis of TA and GAS in mice after adenovirus (Ad) injection with DEX treatment, n = 6. (C and D) Representative H&E staining of TA and GAS. (E) Laminin staining of myofiber cross section of TA muscle; scale bars, 100 μm. (F and G) Related myofiber CSA and frequency of distribution for CSA of TA muscle, n = 6. (H) Laminin staining of myofiber cross section of GAS muscle; scale bars, 100 μm. (I and J) Related CSA and frequency of distribution for CSA of GAS muscle a, n = 6. (K to M) Western blot analysis of protein levels of MyHC, Atrogin-1, and MuRF-1 in TA and GAS muscle. GAPDH was used as the loading control, n = 4. Data are means ± SEM; Student’s t test and paired t test were used in (A) and (B); unpaired t test was used for the others, *P ≤ 0.05, **P ≤ 0.01, #P ≤ 0.1.