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. 2023 Jul 5;45(10):2300047. doi: 10.1002/bies.202300047

FIGURE 1.

FIGURE 1

Schematic representation of erythropoiesis. S0‐low to S5 mark seven defined cellular stages of erythropoiesis representing an immunophenotyping‐based purification strategy[ 7 ] that allows the isolation of the desired population from mouse fetal livers. The stages of erythroid differentiation are shown starting with Hematopoietic Stem Cells (HSC) committing, amongst other lineages, to the erythroid progenitors (burst colony forming unit and colony forming unit erythroid, BFUe and CFUe respectively). α‐globin expression is first detected and progressively increases as cells differentiate from proerythroblasts to mature red blood cells, as indicated by the gradually increasing red colour in the red triangle. The schematic representation of the progressively maturing erythroid cells highlight the morphologically distinguishable stages both in the varying size and hemoglobinisation states of the cells.