Fig. 7. The development of a GSH-responsive-miR-34a delivery platform utilizing PSM termed PSM/miR-34a, coupled with an illustration into its endocytic uptake and intracellular uptake mechanisms. (A) Preparation of the glutathione (GSH)-responsive miR-34a delivery system, PSM/miR-34a. (B) Mechanism of endocytosis and transport designed to enhance the antitumor and anti-metastasis effects in the treatment of orthotopic triple-negative breast cancer. This figure was reproduced from ref. 97 with permission from Wiley Online Library, copyright (2023).