Fig. 3.

Locomotor activity and anxiety-related behaviors after medial septum lesioning. Reduced anxiety-related behavior is observed in 192-IgG-injected animals, evidenced by the number of entries into the open arms of the elevated plus-maze (A) as well as the time spent in such arms (B). C Supports this notion by evaluating the time that the animals spent in the center of the open field box. D No altered locomotion activity was observed in any of the evaluated groups. Graphs represent the mean ± SEM (*p < 0.05; ***p < 0.001). PBS, phosphate buffered saline