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. 2024 Mar 5;61(10):1–21. doi: 10.1007/s12035-024-04069-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values from the fimbria, dorso-medial thalamus, and amygdala of control and lesioned rats. The graphs show the mean and standard error per group. The dotted line indicates the day of the surgery. A In the case of the fimbria, FA values from control and PBS groups show a pattern of increase over time; this effect was not observed when injecting the saporins. B When comparing ADC values, only control animals show a significant increase after 2 weeks of post-injection; moreover, the third time-point shows that GAT1-saporin-injected animals are the group with statistically significant changes (longitudinal and between groups). The GAT1-saporin injection into the medial septum also decreased FA and ADC values of the dorso-medial thalamus (C and D) and amygdala (E and F). Plus sign ( +), multiple comparisons two-way ANOVA; asterisk (*), post-hoc between group differences; ampersand (&), post-hoc within-group difference with respect to baseline (one or two symbols for p < 0.05 and 0.01, respectively). PBS, phosphate buffered saline; w, weeks