Fig. 3.

Cellular composition of the ventricular–subventricular zone (V-SVZ) [24]. Coronal section of adult mouse brain is shown in the upper right. The V-SVZ region indicated by the black arrow is shown enlarged in the lower left. Type B1 cells (blue; GFAP-positive) are the astrocytes that serve as the V-SVZ stem cell. These can divide and produce type C cells (green; Nestin-positive), which are rapidly dividing, transit amplifying cells. Type C cells give rise to type A cells (red; DCX-positive), the migratory neuroblasts. A blood vessel (BV, brown) is shown at the right. The apical surface of type B1 cells has a primary cilium and makes contact with the ventricle, which is at the left. These apical surfaces are found at the center of a “pinwheel” composed of multiciliated ependymal cells (yellow). The V-SVZ can be subdivided into three domains based on the structure and spatial arrangement of type B1 cells: Domain I (apical) contains the type B1 cells apical process and the body of ependymal cells; domain II (intermediate) contains the cell body of most type B1 cells, which are in contact with the type C and A cells; and domain III (basal) contains the B1 cell’s basal process with end-feet on blood vessels