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. 2024 Sep 20;15:8118. doi: 10.1038/s41467-024-51856-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Human heart is digested to isolate single cardiomyocytes, which are field stimulated to produce a regular pattern of contractility transients. These cells are phenotypically stable and provide a robust preclinical assay with high translational validity. b Representative traces capturing contraction-induced change in sarcomere length after administration of vehicle, noribogaine and oxa-noribogaine solutions. c Noribogaine demonstrates pro-arrhythmic potential by causing after-contractions and contraction failures in cardiomyocytes as quantified in the plot, providing validation of this assay for the iboga compounds. No pro-arrhythmic potential was detected for oxa- or epi-oxa-noribogaine (for donor information and replicates see Supplementary Fig. S8). Source data are provided in the Source Data file. Alternans % (percentage of repetitive alternating short and long contractility amplitude transients), STV % (Short-Term Variability in percentage).