Table 2.
Neurodevelopmental delay in each domain of the Japanese translation of the Ages and Stages Questionnaire (Third Edition) in children, according to the cumulative number of general anesthesia exposure before 1 year of age
| None n (%) |
Once n (%) |
≥ 2 times n (%) |
|
|---|---|---|---|
| 12 months | |||
| Subjects (n = 63,273) | 62,681 | 505 | 87 |
| Communication | 66 (0.1) | 1 (0.2) | 3 (3.4) |
| Gross motor | 3,399 (5.4) | 64 (12.7) | 25 (28.7) |
| Fine motor | 3,531 (5.6) | 46 (9.1) | 20 (23.0) |
| Problem solving | 3,126 (5.0) | 44 (8.7) | 18 (20.7) |
| Personal–social | 690 (1.1) | 16 (3.2) | 3 (3.4) |
| 18 months | |||
| Subjects (n = 58,731) | 58,191 | 458 | 82 |
| Communication | 1,198 (2.1) | 18 (3.9) | 7 (8.5) |
| Gross motor | 2,539 (4.4) | 61 (13.3) | 17 (20.7) |
| Fine motor | 2,362 (4.1) | 39 (8.5) | 9 (11.0) |
| Problem solving | 2,205 (3.8) | 40 (8.7) | 9 (11.0) |
| Personal–social | 1,369 (2.4) | 28 (6.1) | 12 (14.6) |
| 24 months | |||
| Subjects (n = 60,131) | 59,580 | 474 | 77 |
| Communication | 2,175 (3.7) | 32 (6.8) | 10 (13.0) |
| Gross motor | 3,257 (5.5) | 54 (11.4) | 19 (24.7) |
| Fine motor | 1,153 (1.9) | 25 (5.3) | 8 (10.4) |
| Problem-solving | 2,344 (3.9) | 37 (7.8) | 9 (11.7) |
| Personal–social | 1,536 (2.6) | 36 (7.6) | 8 (10.4) |
| 30 months | |||
| Subjects (n = 58,429) | 57,888 | 459 | 82 |
| Communication | 2,598 (4.5) | 44 (9.6) | 12 (14.6) |
| Gross motor | 2,330 (4.0) | 39 (8.5) | 18 (22.0) |
| Fine motor | 3,166 (5.5) | 47 (10.2) | 11 (13.4) |
| Problem solving | 3,114 (5.4) | 42 (9.2) | 14 (17.1) |
| Personal–social | 1,772 (3.1) | 38 (8.3) | 10 (12.2) |
| 36 months | |||
| Subjects (n = 59,401) | 58,581 | 469 | 81 |
| Communication | 2,090 (3.6) | 41 (8.7) | 10 (12.3) |
| Gross motor | 2,405 (4.1) | 39 (8.3) | 16 (19.8) |
| Fine motor | 4,130 (7.0) | 54 (11.5) | 16 (19.8) |
| Problem solving | 4,054 (6.9) | 54 (11.5) | 10 (12.3) |
| Personal–social | 1,718 (2.9) | 33 (7.0) | 11 (13.6) |
| 42 months | |||
| Subjects (n = 58,040) | 57,512 | 490 | 78 |
| Communication | 1,500 (2.6) | 28 (6.2) | 9 (11.5) |
| Gross motor | 2,328 (4.0) | 43 (9.6) | 15 (19.2) |
| Fine motor | 2,785 (4.8) | 42 (9.3) | 9 (11.5) |
| Problem solving | 3,044 (5.3) | 43 (9.6) | 13 (16.7) |
| Personal–social | 2,353 (4.1) | 42 (9.3) | 12 (15.4) |
| 48 months | |||
| Subjects (n = 56,270) | 55,756 | 439 | 75 |
| Communication | 2,367 (4.2) | 41 (9.3) | 8 (10.7) |
| Gross motor | 2,980 (5.3) | 57 (13.0) | 15 (20.0) |
| Fine motor | 3,494 (6.3) | 46 (10.5) | 19 (25.3) |
| Problem solving | 1,806 (3.2) | 38 (8.7) | 8 (10.7) |
| Personal–social | 2,916 (5.2) | 42 (9.6) | 11 (14.7) |