Fig. 4.

H5N2-VLP adjuvanted with Alum plus FMDV VP3 or 71VG is a potential candidate for chicken vaccination The immunogenicity of the clade 2.3.4.4c H5N2-VLP vaccine was assessed in chickens. The VLP vaccine was adjuvanted with either Alum and VP3 (25 μg) (A) or 71VG (B) at different doses (16 HAU or 64 HAU). After the primary vaccination, the same booster dose was administered on day 14 (indicated by an open arrow). The figure shows the HI antibody titers induced by each vaccine formulation with different adjuvants and antigen doses. Each circle represents an individual animal. A HI titer of ≥1:10 was defined as seroconversion (dash line).