Table 3.

Lean and fat mass of the regional districts, before and after at least 18 months of aromatase inhibitors (AI) therapy, in a dietary counseling (cohort A) and in a control cohort (cohort B).

Parameter	Cohort A		Cohort B		Pa
	Mean (95 % CI)	% change from before Mean (95 % CI)	Mean (CI 95 %)	% change from before Mean (95 % CI)
Trunk lean mass (kg)
Before AI therapy	20.71 (20.18–21.24)	−3.4	20.43 (19.89–20.97)	−3.1	0.779
After AI therapy	20.07 (19.44–20.50)	(-5.1 to −1.6)	19.78 (19.25–20.31)	(-4.5 to −1.7)
Pb	< 0.001		< 0.001
Left arm lean mass (kg)
Before AI therapy	1.91 (1.84–1.97)	−5.2	1.84 (1.78–1.90)	−1.0	0.004
After AI therapy	1.80 (1.74–1.87)	(-7.1 to −3.3)	1.83 (1.77–1.88)	(-3.1 to 1.2)
pb	< 0.001		0.061
Right arm lean mass (kg)
Before AI therapy	1.99 (1.92–2.06)	0.1	1.97 (1.91–2.02)	−0.04	0.796
After AI therapy	1.97 (1.90–2.04)	(-2.6 to 2.8)	1.96 (1.90–2.02)	(-2.7 to 2.0)
pb	0.474		0.686
Left leg lean mass (kg)
Before AI therapy	6.31 (6.11–6.51)	−3.1	5.96 (5.77–6.16)	−0.3	0.027
After AI therapy	6.11 (5.91–6.32)	(-5.0 to −1.2)	5.94 (5.75–6.14)	(-1.9 to 1.3)
pb	<0.001		0.320
Right leg lean mass (kg)
Before AI therapy	6.78 (5.91–7.66)	−2.8	6.07 (5.88–6.26)	−0.5	0.176
After AI therapy	6.23 (6.03–6.43)	(-5.4 to −0.2)	6.03 (5.83–6.22)	(-2.5 to 1.6)
pb	0.010		0.550
Head lean mass (kg)
Before AI therapy	3.04 (2.96–3.12)	−6.1	3.02 (2.96–3.09)	−6.3	0.862
After AI therapy	2.86 (2.80–2.92)	(-8.2 to −4.0)	2.82 (2.77–2.86)	(-8.1 to −4.5)
p	< 0.001		< 0.001
Trunk fat mass (kg)
Before AI therapy	11.49 (10.51–12.47)	15.7	11.36 (10.33–12.40)	12.0	0.250
After AI therapy	12.69 (11.70–13.67)	(10.8–20.6)	12.45 (11.48–13.43)	(8.0–16.0)
pb	< 0.001		< 0.001
Left arm fat mass (kg)
Before AI therapy	1.54 (1.42–1.66)	11.7	1.46 (1.34–1.58)	6.4	0.124
After AI therapy	1.65 (1.53–1.78)	(0.9–16.4)	1.52 (1.40–1.63)	(1.6–11.2)
pb	< 0.001		0.184
Right arm fat mass (kg)
Before AI therapy	1.55 (1.4–1.68)	7.6	1.48 (1.36–1.60)	4.5	0.314
After AI therapy	1.62 (1.50–1.75)	(3.6–11.6)	1.49 (1.39–1.59)	(0.1–9.0)
pb	0.010		0.445
Left leg fat mass (kg)
Before AI therapy	4.38 (4.10–4.66)	8.2	4.28 (4.00–4.57)	4.6	0.113
After AI therapy	4.69 (4.38–5.00)	(4.8–11.6)	4.44 (4.14–4.74)	(1.6–7.6)
pb	< 0.001		0.012
Right leg fat mass (kg)
Before AI therapy	4.66 (4.36–4.95)	5.5	4.45. (4.16–4.75)	4.8	0.787
After AI therapy	4.88 (4.56–5.20)	(2.6–8.3)	4.60 (4.29–4.90)	(1.1–8.6)
pb	0.002		0.009
Head fat mass (kg)
Before AI therapy	0.90 (0.88–0.93)	2.3	0.89 (090–0.91)	0.3	0.254
After AI therapy	0.92 (0.90–0.94)	(-0.2 to 4.8)	0.90 (0.87–0.90)	(-2.0 to 2.7)
Pb	0.092		0.327

CI: Confidence interval.

^aMann-Whitney U test for the comparison of the before-after differences between the two cohorts.

^bWilcoxon signed-rank test for the before-after comparison for each cohort.