Table 2.
Summary of Clinical Application of Herbs in Treatment of Migraine
| Intervention | Model | Method | Mechanisms | Migraine Types | Model Methods | Intervention | Comparison | Refs. |
|---|---|---|---|---|---|---|---|---|
| Herbs | Rats | Animal experiment | 1. Improved the metabolic profile of serum and TCC in migraine rats, mainly involved in amino acid metabolism (glutamate) 2. Increased the expressions of glutamine synthetase |
NA | NTG-induced migraine rats | Dachuanxiong prescription | Blank control | [63] |
| 1. Increased the levels of 5-HT 2. Decreased the levels of CGRP |
NA | Inflammatory soup-induced chronic migraine rats | Wuzhuyu Decoction | Blank control | [64] | |||
| 1. Increased cerebral blood flow 2. Decreased the expression of CGRP, and regulated the release of CGRP 3. Relieved neurogenic inflammation |
NA | NTG-induced migraine rats | Chuanxiong Rhizoma and Cyperi Rhizoma | Blank control | [65] | |||
| 1. Decreased the plasma CGRP and serum NO levels 2. Reduced NF-κB p65 and pro-inflammatory cytokines, including IL-1β and COX-2 in the brainstem |
NA | Glyceryl trinitrate induced migraine rats | Du Liang soft capsule | Blank control | [68] | |||
| 1. Suppressed glutamate 2. Decreased BBB permeability and maintain its integrity through regulating MMP-9 in migraine rats |
NA | NTG-induced migraine rats | Chuanxiong and Gastrodia elata | Blank control | [76] | |||
| 1. Increased the permeation rate across the BBB | NA | Blood-stasis migraine model | TMP and FA | Blank control | [77] | |||
| Network pharmacology and animal experiment | 1. Increased the expression level of 5-HT 2. Reduced the expression of CGRP, NF-κB, c-fos and IL-1β 3. Inhibited NF-κB and phospho-NF-κB levels |
NA | NTG-induced migraine rats | Yufeng Ningxin tablet | Blank control | [69] | ||
| Rats | Animal experiment | 1. Enhanced the 5-HT contents and declined NO contents 2. Inhibited the NGF/TRPV1/COX-2 signaling pathway |
NA | NTG-induced migraine rats | Shaoyao Gancao Decoction | Blank control | [71] |
Abbreviations: BBB, Blood-brain barrier; CGRP, Calcitonin gene-related peptide; COX2, Cyclooxygenase-2; FA, Ferulic acid; IL-1β, Interleukin-1β; MMP-9, Matrix metalloproteinase-9; NA, Not applicable; NF-κB, Nuclear factor-kappa B; NGF, Neurotrophic factor; NO, Nitric oxide; NTG, nitroglycerine; TCC, Trigeminocervical complex; TMP, Tetramethylpyrazine; TRPV1, Transient receptor potential vanillic acid subfamily protein 1 receptor; 5-HT, 5-hydroxytryptamine.