Fig. 4.

CDI recurrence rates in subgroups. CDI Clostridioides difficile infection; PPI proton pump inhibitor; VOS VOWST™ oral spores. Two patients enrolled in ECOSPOR III had missing or negative assay results for the qualifying episode and are not included. Two patients were enrolled in ECOSPOR IV on the basis of a positive loop-mediated isothermal amplification assay result and are also not included. One rollover patient in ECOSPOR IV was diagnosed by PCR alone; however, in the integrated analysis, all baseline information for rollover patients was recorded from ECOSPOR III and this patient is therefore included in the category “qualifying episode defined by toxin with/without PCR”. Four patients had missing CCI scores; 12 patients had missing baseline creatine clearance rate; one patient had missing data for number of prior CDI episodes. [1] Charlson Comorbidity Index (CCI) scores adjusted for age [20]