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. 2024 Aug 28;27(9):110837. doi: 10.1016/j.isci.2024.110837

Figure 1.

Figure 1

NK and monocyte cell frequencies are altered in pediatric cancer patients

(A) Manual gating strategy used to split immune cells into CD3−CD19−and CD3+CD19+subsets.

(B) Concatenated FCS files for both pediatric healthy (n = 19) and pediatric cancer patients (n = 20) were analyzed by UMAP dimensionality reduction. The frequency and identify of main immune subsets is shown.

(C) Frequency of the main immune subsets for all healthy children (open symbols) and pediatric cancer patients (closed symbols) expressed as a percentage of total CD45+ cells. Error bars show the mean ± 1 standard deviation. p values were calculated using Wilcoxon ranked sum tests with false discovery rate at 5% and correction using the Benjamini-Hochberg method. Significant results are indicated: ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.