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. Author manuscript; available in PMC: 2024 Sep 22.
Published in final edited form as: ACS Biomater Sci Eng. 2022 Dec 5;9(1):409–426. doi: 10.1021/acsbiomaterials.2c00853

Figure 4.

Figure 4.

Cytotoxicity evaluation for the oxygen-generating scaffolds using lactate dehydrogenase (LDH) assay for the samples that were cultured a. Under normoxia without catalase, b. Under normoxia with catalase, c. Under hypoxia without catalase, and d. Under hypoxia with catalase. E. The comparative LDH activity analyses within the OGM3 scaffolds under all culture conditions showed no increase in the LDH levels over the 35-day culture period. The OGM3 scaffolds therefore indicated no cytotoxicity whereas the pristine GelMA, OGM0, OGM4, and OGM5 scaffolds showed an increasing LDH levels in comparison. The OGM3 scaffolds demonstrated the most favorable cellular response and did not elicit cytotoxicity under all of the culture conditions.