Table 3:
Estimated hazard ratios and their 95% confidence intervals (CIs) of risk factors associated with the onset of GHD
| Parameter | Observation-deletion (N=6196) |
Event-deletion (n=7177) |
Simple replacement (n=7177) |
Interval censored (n=7177) |
||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | HR | 95% CI | HR | 95% CI | HR | 95% CI | |
| BMI-Normal | Ref. | Ref. | Ref. | Ref. | ||||
| BMI-Underweight | 1.42 | (1.12, 1.81) | 1.24 | (0.97, 1.57) | 1.57 | (1.35, 1.83) | 1.48 | (1.25 1.76) |
| BMI-Overweight | 0.82 | (0.67, 1.01) | 0.86 | (0.70, 1.06) | 0.78 | (0.68, 0.88) | 0.81 | (0.72, 0.91) |
| BMI-Obese | 0.67 | (0.52, 0.85) | 0.72 | (0.56, 0.92) | 0.75 | (0.65, 0.87) | 0.74 | (0.64, 0.84) |
| Brain RT [0,20) Gy | Ref. | Ref. | Ref. | Ref. | ||||
| Brain RT [20,30) Gy | 1.14 | (0.91, 1.42) | 1.14 | (0.91, 1.43) | 0.71 | (0.60, 0.85) | 0.94 | (0.82, 1.09) |
| Brain RT [30,50) Gy | 2.39 | (1.85, 3.08) | 1.98 | (1.53, 2.55) | 2.33 | (1.95, 2.78) | 2.65 | (2.26, 3.12) |
| Brain RT 50+ Gy | 3.07 | (2.51, 3.77) | 2.00 | (1.63, 2.45) | 4.17 | (3.65, 4.77) | 4.51 | (3.99, 5.10) |
| Female | Ref. | Ref. | Ref. | Ref. | ||||
| Male | 1.49 | (1.26, 1.75) | 1.51 | (1.28, 1.78) | 1.27 | (1.15, 1.40) | 1.20 | (1.09, 1.32) |
| Age at diagnosis | 0.28 | (0.25, 0.32) | 0.29 | (0.25, 0.33) | 0.51 | (0.48, 0.55) | 0.51 | (0.48, 0.54) |