Table 3.

Results of the mediation effects analysis.

Air pollutants	Inflammatory protein	Lung function and CRDs associated with exposures	OR (95%CI)	p-value
	OR (95%CI), p-value as outcome associated with air pollutants
PM2.5	Interleukin-2 0.596 (0.436–0.816) p = 0.001**	FEV1	0.998 (0.978–1.019)	0.876
		COPD	1.001 (0.936–1.069)	0.996
	Neurotrophin-3 0.697 (0.529–0.920) p = 0.011*	FEV1	1.004 (0.984–1.025)	0.693
		COPD	1.030 (0.966–1.098)	0.374
PM10	Axin-1 0.840 (0.707–0.998) p = 0.048*	FEV1	0.968 (0.946–0.990)	0.005**
		FVC	0.987 (0.964–1.010)	0.267
		FEV1/FVC	0.961 (0.939–0.984)	0.001**
	Natural killer cell receptor 2B4 0.809 (0.694–0.944) p = 0.007**	FEV1	0.995 (0.978–1.012)	0.554
		FVC	0.996 (0.979–1.013)	0.644
		FEV1/FVC	0.990 (0.974–1.006)	0.234
	CD40L receptor 0.808 (0.694–0.940) p = 0.006**	FEV1	1.001 (0.990–1.011)	0.933
		FVC	0.996 (0.986–1.007)	0.513
		FEV1/FVC	1.003 (0.993–1.013)	0.541
	U-cell surface glycoprotein CD6 isoform 0.830 (0.710–0.969) p = 0.018*	FEV1	0.998 (0.990–1.006)	0.651
		FVC	1.001 (0.992–1.009)	0.936
		FEV1/FVC	0.991 (0.983–0.999)	0.041*
	Interleukin-17A 1.335 (1.123–1.587) p = 0.001**	FEV1	0.966 (0.946–0.987)	0.001**
		FVC	0.968 (0.9470.991)	0.005**
		FEV1/FVC	0.998 (0.977–1.018)	0.817
	Interleukin-33 0.801 (0.674–0.952 P = 0.01*)	FEV1	1.018 (0.995–1.042)	0.130
		FVC	1.028 (1.005–1.052)	0.018*
		FEV1/FVC	0.984 (0.957–1.011)	0.248
	STAM binding protein 0.827 (0.708–0.966) p = 0.016*	FEV1	0.999 (0.972–1.027)	0.953
		FVC	0.999 (0.973–1.028)	0.994
		FEV1/FVC	0.999 (0.971–1.027)	0.922
NO2	Matrix metalloproteinase-10 1.436 (1.134–1.819) p = 0.003**	COPD	1.005 (0.971–1.040)	0.774
		FEV1/FVC	0.998 (0.980–1.017)	0.826

PM, particulate matter; NO2, nitrogen oxides; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; CRDs, chronic respiratory disease; COPD, chronic obstructive pulmonary disease; IPF, idiopathic pulmonary fibrosis; ^*p < 0.05; ^**p < 0.01.