Figure 8.

Proposed mechanism for the BFstatin-mediated inhibition of the V. vulnificus biofilm formation. (A) Active BrpR binds to its target promoter DNA using the DNA-binding domain, and the expression of biofilm genes is induced, leading to the formation of biofilms. (B) In contrast, BFstatin modifies the molecular structure of BrpR and thereby inhibits its binding to the target promoter DNA. Consequently, the expression of biofilm genes is not induced, resulting in the inhibition of biofilm formation. DBD, DNA-binding domain.