Figure 5.

Model summarizing how epigenetic modifications orchestrate the interplay between genic and TEs regions. There is a clear segregation between the different chromatin constituents in the wild type: constitutive heterochromatin domains (red), Polycomb domains (blue) and active domains (green). The distribution of H3K27me3 (blue), H3K9me2 (red) and H3K27me1 (brown) marks coincides with the establishment of separate compartments. In contrast, the compartmental delineation is considerably more diffuse in ddm1. The ectopic depositions of H3K27me3 and the general reshuffling of the other histone marks induce new interactions, particularly between genic and TEs regions (violet). Created with Biorender.