Table 2.
Tablet |
SSG |
PVP K-30 |
Carr index |
Hausner ratio |
Hardness |
Friability |
Disintegrating time |
Drug release |
||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Code | [mg] | [mg] | [%] | SD | SD | [kp] | SD | [%] | SD | [min.] | SD | [%] | SD | |
Ta | 40.00 | 16.00 | 16.10 | 0.13 | 1.19 | 0.01 | 4.03 | 0.04 | 0.47 | 0.10 | 0.59 | 0.10 | 84.91 | 0.92 |
Tb | 32.00 | 24.00 | 18.75 | 0.28 | 1.25 | 0.01 | 7.10 | 0.07 | 0.57 | 0.11 | 1.37 | 0.09 | 92.25 | 0.53 |
Tc | 24.00 | 32.00 | 20.45 | 0.23 | 1.29 | 0.01 | 9.23 | 0.14 | 0.66 | 0.12 | 7.75 | 0.13 | 97.31 | 0.66 |
Tp | 33.60 | 22.40 | 18.00 | – | 1.24 | – | 6.56 | – | 0.55 | – | 3.20 | – | 90.25 | – |
To | 33.60 | 22.40 | 18.10 | 0.10 | 1.24 | 0.02 | 6.51 | 0.22 | 0.54 | 0.14 | 3.30 | 0.16 | 90.30 | 0.54 |
Tp (prediction tablet): composition and quality prediction follow software design expert.
To (optimum tablet): the composition follows the software design expert, and the quality value is the result of the verification experiment.