Table 2.
Incidence and volume of new brain lesions on brain magnetic resonance imaging after 2 years of follow-up, overall and in blood pressure categories.
| Ischemic lesions | White matter lesions | Microbleeds | Composite endpointa |
||||
|---|---|---|---|---|---|---|---|
| n (%) | Incidence | Volume, mm3 | Incidence | Volume, mm3 | Incidence | Incidence | |
| Overall | 1,213 | 66 (5.4) | 278 [116, 653] | 223 (18.4) | 108 [45, 284] | 135 (11.5) | 332 (28.0) |
| Blood pressure categories | |||||||
| Optimal | 211 (17.4) | 10 (4.7) | 534 [203, 799] | 32 (15.2) | 138 [65, 315] | 21 (10.3) | 48 (23.3) |
| Normal | 249 (20.5) | 14 (5.6) | 477 [109, 993] | 55 (22.1) | 105 [41, 590] | 32 (13.2) | 79 (32.1) |
| High normal | 265 (21.8) | 15 (5.7) | 315 [134, 608] | 47 (17.7) | 75 [42, 179] | 24 (9.5) | 67 (26.2) |
| Hypertension grade 1 | 348 (28.7) | 15 (4.3) | 207 [48, 269] | 64 (18.4) | 95 [35, 335] | 41 (12.1) | 99 (29.1) |
| Hypertension grade 2 and 3 | 140 (11.5) | 12 (8.6) | 332 [112, 494] | 25 (17.9) | 159 [90, 249] | 17 (12.4) | 39 (28.5) |
| P-value | 0.43 | 0.22 | 0.43 | 0.21 | 0.70 | 0.29 | |
Data are numbers (%) or median [interquartile range]. BP, blood pressure.
Groups were compared using χ2 tests or Kruskal-Wallis Tests, as appropriate.
Optimal BP indicates systolic BP <120 and diastolic BP <80 mmHg; Normal BP, systolic BP 120–129 mmHg and/or diastolic BP 80–84 mmHg; High normal BP, systolic BP 130–139 mmHg and/or diastolic BP 85–89 mmHg; Hypertension grade 1, systolic BP 140–159 mmHg and/or diastolic BP 90–99 mmHg; Hypertension grade 2 and 3, systolic BP ≥160 and/or diastolic BP ≥100 mmHg.
Valid patients for microbleeds n = 1,174; Valid patients for composite endpoint n = 1,185.
Composite endpoint for microvascular damage of white matter lesions, microbleeds and small non-cortical infarcts.