Table 3.
Comparison of the two sample Mendelian randomization results between alcohol intake frequency and cancer sites.
| Cancer Site | Sample Size | Cases | Before Removing Outliers | After Removing Outliers | ||
|---|---|---|---|---|---|---|
| OR (95% CI) | p Value | OR (95% CI) | p Value | |||
| Stomach | 174,006 | 633 | 0.48 (0.23–1.00) | 0.05 | 1.77 (0.97–3.23) | 0.0036 |
| Liver | 218,488 | 304 | 0.96 (0.34–2.71) | 0.9386 | 0.82 (0.33–2.07) | 0.6813 |
| Lung | 217,165 | 1627 | 0.92 (0.58–1.45) | 0.7169 | 1.08 (0.73–1.58) | 0.7088 |
| Colon | 174,006 | 1803 | 1.11 (0.768–1.616) | 5.69 × 10−1 | 1.83 (0.99–3.35) | 0.0022 |
| Thyroid | 174,006 | 989 | 1.12 (0.57–2.18) | 0.7411 | 1.15 (0.65–2.04) | 0.6219 |
| Cervix | 99,321 | 1648 | 0.99 (0.54–1.80) | 0.9665 | 0.85 (0.55–1.30) | 0.4488 |
| Breast | 115,178 | 8401 | 0.84 (0.61–1.15) | 0.2786 | 0.93 (0.84–1.02) | 0.1189 |
| Prostate | 88,902 | 6311 | 0.99 (0.71–1.38) | 0.9552 | 0.93 (0.72–1.21) | 0.6027 |
| Colorectal | 215,770 | 3022 | 0.79 (0.57–1.11) | 0.1822 | 0.85 (0.67–1.09) | 0.1666 |
| Bladder | 174,006 | 1115 | 1.19 (0.69–2.05) | 0.5414 | 1.08 (0.88–1.30) | 0.5002 |
| Larynx | 218,612 | 180 | 0.59 (0.15–1.27) | 0.4409 | 0.69 (0.19–2.45) | 0.5743 |
| Lip-Oral-Pharynx | 218,666 | 126 | 1.14 (0.20–6.64) | 0.8808 | 1.02 (0.28–3.78) | 0.7621 |
| Oral cavity | 4151 | 1223 | 2.32 (0.91–5.92) | 0.0768 | NA | NA |
| Brain | 218,328 | 464 | 1.35 (0.58–3.14) | 0.4905 | 1.16 (0.57–2.36) | 0.6839 |
| Biliary tract | 174,006 | 109 | 1.44 (0.25–8.43) | 0.6776 | 3.86 (0.89–16.85) | 0.0722 |
| Oesophagus | 218,560 | 232 | 2.58 (0.74–9.00) | 0.1380 | 3.44 (1.19–9.89) | 0.0217 |