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. 2024 Sep 16;14(3):1256–1267. doi: 10.3390/jox14030071

Figure 2.

Figure 2

Effect of pharmacological activation of rPXR on testosterone secretion by rat primary LCs. (A). LCs were isolated from 35-day-old male rats. Pooled LCs were incubated in the culture media and treated with either DMSO (n = 6) or 10 µM PCN (n = 6) for 24 h. The media was aspirated and collected after 24 h treatments to measure the T levels using RIA. Data represent mean ± SD from six independent experiments. Statistical significance was determined using an unpaired Students t test. (B). Both DMSO and PCN-treated rat primary LCs were incubated in the culture medium without (basal) (n = 3) or with 100 ng/mL LH (LH) (n = 3) for 3 h. The media aliquots were collected to determine T production using RIA. Results are shown as the mean ± S.D. Determined by ANOVA and a Tukey’s multiple comparisons test.