Table 1.
Clinical, radiological and biochemical data of the study population.
| Total (n = 213) | mRS 0–2 (n = 50) | mRS 3–6 (n = 163) | p-Value* | |
|---|---|---|---|---|
| Baseline data | ||||
| Mean age, years (±SD) | 76.1 (±12.5) | 73.5 (±10.8) | 76.9 (±12.9) | 0.092 |
| Sex, female, n (%) | 100 (47.0) | 31 (62.0) | 69 (42.0) | 0.016 |
| Pre stroke mRS 0–2, n (%) | 177 (83.0) | 50 (100.0) | 127 (78.0) | 0.0005 |
| Wake-up stroke, n (%) | 68 (32.0) | 12 (24.0) | 56 (34.0) | 0.22 |
| Mean creatinin, mg/dl (±SD) | 1.1 (±0.7) | 1.0 (±0.4) | 1.1 (±0.7) | 0.59 |
| Mean GFR, ml/min/173 cm2 (±SD) | 71.4 (±27.3) | 75.8 (±22.0) | 70.0 (±28.6) | 0.10 |
| Time from onset to mechanical recanalisation, hours,a,b hours, mean (±SD) | 4.3 (±3.1) | 3.6 (±1.8) | 4.5 (±3.4) | 0.40 |
| Vascular risk factors, n (%) | ||||
| Hypertension | 145 (68.1) | 32 (64.0) | 115 (70.6) | 0.30 |
| Diabetes mellitus | 42 (19.7) | 7 (14.0) | 35 (21.5) | 0.31 |
| Heart failure | 31 (14.6) | 4 (8.0) | 27 (16.6) | 0.17 |
| Atrial fibrillation | 99 (46.5) | 26 (52.0) | 73 (44.8) | 0.42 |
| Stroke severity, c median [IQR] | ||||
| NIHSS on admission | 13 [9; 17] | 9.5 [8; 14] | 14 [10; 17] | 0.0003 |
| NIHSS at 24 h | 12 [5; 20] | 3 [1; 5] | 15 [8.5; 22] | <0.0001 |
| NIHSS at 72 h | 9.5 [3; 16] | 2 [0; 4] | 13 [7; 19] | <0.0001 |
| NIHSS at discharge | 5 [1; 12] | 1 [0; 3] | 9.5 [4; 14] | <0.0001 |
| Etiology, n (%) | ||||
| Large artery atherosclerosis | 26 (12.2) | 8 (16.0) | 18 (11.0) | 0.46 |
| Cardioembolism | 98 (46.0) | 27 (54.0) | 71 (43.6) | 0.26 |
| Unknown/others | 89 (41.8) | 15 (30.0) | 74 (45.4) | 0.07 |
| Neuoradiologic data | ||||
| Blood vessel occluded, n (%) | ||||
| ICA | 48 (22.5) | 6 (12.0) | 42 (25.8) | 0.0094 |
| M1 | 99 (46.5) | 22 (44.0) | 77 (47.2) | 0.0211 |
| M2 | 48 (22.5) | 13 (26.0) | 35 (21.5) | 0.0088 |
| ASPECTS, median [IQR] | ||||
| ASPECTS on admission | 7.0 [6.0; 9.0] | 8.5 [8.0; 9.0] | 7 [6; 8] | <0.0001 |
| ASPECTS 24–72 h | 7.0 [5.0; 8.0] | 8.0 [7.0; 9.0] | 6 [3; 7] | <0.0001 |
| Collateral status, n (%) | ||||
| 1 | 95 (44.6) | 13 (26.0) | 82 (50.3) | 0.0032 |
| 2 | 56 (26.3) | 17 (34.0) | 39 (23.9) | 0.20 |
| 3 | 32 (15.0) | 9 (18.0) | 23 (14.1) | 0.65 |
| Not assessable | 30 (14.0) | 11 (22.0) | 19 (11.7) | |
| Acute treatment, n (%) | ||||
| Systemic lysis | 85 (40.0) | 24 (48.0) | 61 (37.0) | 0.20 |
| Mechanical recanalisation | 158 (74.0) | 32 (64.0) | 126 (77.3) | 0.07 |
| TICI ⩾ 2b | 132 (84.0) | 32 (100.0) | 100 (79.4) | 0.013 |
| Biomarker data, median [IQR] | ||||
| Time from onset to blood sample, hours a | 31 [21; 59] | 27 [18; 48] | 35 [22; 63] | 0.07 |
| NfL, pg/ml | 96 [51; 228] | 41 [29; 62] | 136 [67; 277] | <0.0001 |
| GFAP, ng/ml | 5.7 [1.5; 22] | 0.7 [0.3; 2.7] | 9.6 [3.0; 33] | <0.0001 |
a
Only patients with clear time windows.
b
Only patients with mechanical recanalization.
c
Deceased patients excluded.
*
Patients with good functional outcome versus poor outcome.Bold values refer to statistically significant.