Table 3.

Comparison of the discrimination (AUROC) of Model A, B, and C with and without the inclusion of blood based biomarkers.

AUROC	Without biomarkers	+NfL	p-value
Model A	0.68 [0.61; 0.77]	0.84 [0.78; 0.90]	p < 0.001
Model B	0.79 [0.73; 0.86]	0.86 [0.80; 0.93]	p = 0.029
Model C	0.73 [0.66; 0.82]	0.85 [0.78; 0.92]	p = 0.005
AUROC	Without biomarkers	+GFAP	p-value
Model A	0.68 [0.61; 0.77]	0.85 [0.79; 0.91]	p < 0.001
Model B	0.79 [0.73; 0.86]	0.87 [0.80; 0.93]	p = 0.003
Model C	0.73 [0.66; 0.82]	0.86 [0.78; 0.92]	p = 0.001
AUROC	Without biomarkers	+NfL and GFAP	p-value
Model A	0.68 [0.61; 0.77]	0.88 [0.83; 0.93]	p < 0.001
Model B	0.79 [0.73; 0.86]	0.88 [0.85; 0.94]	p < 0.001
Model C	0.73 [0.66; 0.82]	0.88 [0.84; 0.94]	p < 0.001