Table 4.

Calibration and overall performance of model A, B, and C.

	Without biomarkers	+NfL	+GFAP	+NfL and GFAP
Model A
Emax	0.06 [0.04; 0.34]	0.07 [0.04; 0.24]	0.07 [0.04; 0.25]	0.08 [0.04; 0.21]
Eavg	0.02 [0.01; 0.05]	0.02 [0.01; 0.06]	0.03 [0.01; 0.07]	0.03 [0.01; 0.05]
Brier Score	0.08 [−0.07; 0.25]	0.28 [0.16; 0.47]	0.33 [0.19; 0.52]	0.38 [0.24; 0.57]
R2	0.11 [0.04; 0.24]	0.36 [0.23; 0.54]	0.41 [0.28; 0.58]	0.47 [0.35; 0.64]
Model B
Emax	0.05 [0.03; 0.26]	0.05 [0.03; 0.25]	0.13 [0.06; 0.25]	0.12 [0.05; 0.23]
Eavg	0.01 [0.01; 0.05]	0.01 [0.01; 0.05]	0.05 [0.02; 0.08]	0.03 [0.01; 0.06]
Brier Score	0.19 [0.05; 0.36]	0.32 [0.19; 0.53]	0.37 [0.20; 0.56]	0.39 [0.27; 0.60]
R2	0.27 [0.16; 0.43]	0.41 [0.30; 0.60]	0.43 [0.29; 0.61]	0.48 [0.38; 0.66]
Model C
Emax	0.03 [0.04; 0.29]	0.08 [0.04; 0.26]	0.08 [0.04; 0.21]	0.11 [0.04; 0.23]
Eavg	0.01 [0.01; 0.06]	0.03 [0.01; 0.06]	0.04 [0.01; 0.06]	0.03 [0.01; 0.06]
Brier Score	0.12 [−0.02; 0.32]	0.30 [0.17; 0.50]	0.32 [0.17; 0.52]	0.37 [0.24; 0.58]
R2	0.18 [0.09; 0.34]	0.38 [0.24; 0.57]	0.41 [0.27; 0.58]	0.47 [0.37; 0.64]