Table 1. Baseline characteristics of mothers and children registered in MoCHiV between January 1986 and December 2022.
| Total | Zurich | Lausanne | Geneva | Basel | Bern | St. Gallen | Ticino | |
| Mothers | ||||||||
| 1041 | 287 | 196 | 180 | 149 | 153 | 58 | 42 | |
| Total registered mothers | ||||||||
| Active patients | 647 (62%) | 150 (52%) | 127 (65%) | 115 (64%) | 95 (64%) | 107 (70%) | 43 (74%) | 24 (57%) |
| Voluntary Discontinuation | 109 (10%) | 28 (10%) | 19 (10%) | 24 (13%) | 14 (9%) | 15 (10%) | 4 (7%) | 8 (19%) |
| Died | 55 (5%) | 23 (8%) | 3 (2%) | 11 (6%) | 7 (5%) | 7 (5%) | 4 (7%) | 1 (2%) |
| Lost to follow-up | 230 (22%) | 86 (30%) | 47 (24%) | 30 (17%) | 33 (22%) | 24 (16%) | 7 (12%) | 9 (21%) |
| Age in years at HIV diagnosis | ||||||||
| Median (IQR) | 26 (23–31) | 26 (23–30) | 27 (23–31) | 26 (23–31) | 26 (23–30) | 27 (2–32) | 27 (23–30) | 27 (24–30) |
| Age in years at birth of the first child in SHCS | ||||||||
| Median (IQR) | 30 (25–35) | 30 (25–35) | 31 (26–35) | 29 (26–35) | 30 (25–34) | 29 (25–34) | 30 (26–33) | 32 (28–36) |
| Ethnicity | ||||||||
| Black | 455 (44%) | 86 (30%) | 111 (57%) | 96 (53%) | 58 (39%) | 86 (56%) | 23 (40%) | 4 (10%) |
| White | 445 (43%) | 164 (57%) | 73 (37%) | 63 (35%) | 64 (43%) | 47 (31%) | 21 (36%) | 26 (62%) |
| Asian | 65 (6%) | 19 (7%) | 3 (2%) | 4 (2%) | 14 (9%) | 13 (8%) | 7 (12%) | 6 (14%) |
| Hispano-American | 37 (4%) | 14 (5%) | 5 (3%) | 3 (2%) | 5 (3%) | 4 (3%) | 2 (3%) | 4 (10%) |
| Unknown | 39 (4%) | 4 (1%) | 4 (2%) | 14 (8%) | 8 (5%) | 3 (2%) | 5 (9%) | 2 (5%) |
| Source of HIV infection | ||||||||
| Heterosexual contact | 818 (79%) | 205 (71%) | 165 (84%) | 146 (81%) | 115 (77%) | 124 (81%) | 44 (76%) | 34 (81%) |
| Intravenous drug use | 152 (15%) | 66 (23%) | 15 (8%) | 18 (10%) | 26 (17%) | 14 (9%) | 11 (19%) | 8 (19%) |
| Perinatal transmission | 18 (2%) | 6 (2%) | 5 (3%) | 5 (3%) | 1 (1%) | 0 (0%) | 1 (2%) | 0 (0%) |
| Blood products | 14 (1%) | 3 (1%) | 4 (2%) | 4 (2%) | 2 (1%) | 1 (1%) | 1 (2%) | 0 (0%) |
| Unknown | 39 (4%) | 7 (2%) | 7 (4%) | 7 (4%) | 5 (3%) | 14 (9%) | 1 (2%) | 0 (0%) |
| Viral load at delivery (n=1446 for all deliveries to include mothers with multiple deliveries) | ||||||||
| Nr of deliveries | 1446 | 388 | 266 | 258 | 201 | 203 | 76 | 54 |
| <50 copies/mL | 814 (56%) | 211 (54%) | 149 (56%) | 145 (56%) | 113 (56%) | 128 (63%) | 36 (47%) | 32 (59%) |
| 50–1000 copies/mL | 132 (9%) | 34 (9%) | 29 (11%) | 19 (7%) | 14 (7%) | 20 (10%) | 9 (12%) | 7 (13%) |
| >1000 copies/mL | 79 (5%) | 27 (7%) | 17 (6%) | 5 (2%) | 18 (9%) | 6 (3%) | 4 (5%) | 2 (4%) |
| Unknown | 421 (29%) | 116 (30%) | 71 (27%) | 89 (34%) | 56 (28%) | 49 (24%) | 27 (36%) | 13 (24%) |
| Children | ||||||||
| 2154 | 591 | 393 | 335 | 324 | 298 | 110 | 103 | |
| Total registered children | ||||||||
| Active patients | 115 (5%) | 33 (6%) | 29 (7%) | 26 (8%) | 14 (4%) | 4 (1%) | 5 (5%) | 4 (4%) |
| Transition to SHCS | 113 (5%) | 29 (5%) | 17 (4%) | 21 (6%) | 18 (6%) | 18 (6%) | 8 (7%) | 2 (2%) |
| Completed follow-up | 1247 (58%) | 373 (63%) | 245 (62%) | 167 (50%) | 189 (58%) | 139 (47%) | 63 (57%) | 71 (69%) |
| Voluntary discontinuation | 101 (5%) | 49 (8%) | 13 (3%) | 16 (5%) | 7 (2%) | 10 (3%) | 2 (2%) | 4 (4%) |
| Died* | 81 (4%) | 31 (5%) | 14 (4%) | 11 (3%) | 6 (2%) | 9 (3%) | 2 (2%) | 8 (8%) |
| Lost to follow-up | 497 (23%) | 76 (13%) | 75 (19%) | 94 (28%) | 90 (28%) | 118 (40%) | 30 (27%) | 14 (14%) |
| Infection status | ||||||||
| Exposed uninfected | 1732 (80%) | 488 (83%) | 331 (84%) | 246 (73%) | 249 (77%) | 248 (83%) | 88 (80%) | 82 (80%) |
| Infected | 285 (13%) | 81 (14%) | 47 (12%) | 52 (16%) | 37 (11%) | 37 (12%) | 16 (15%) | 15 (15%) |
| Unknown | 137 (6%) | 22 (4%) | 15 (4%) | 37 (11%) | 38 (12%) | 13 (4%) | 6 (5%) | 6 (6%) |
| Sex | ||||||||
| Male | 1099 (51%) | 315 (53%) | 191 (49%) | 161 (48%) | 161 (50%) | 161 (54%) | 57 (52%) | 53 (51%) |
| Female | 1055 (49%) | 276 (47%) | 202 (51%) | 174 (52%) | 163 (50%) | 137 (46%) | 53 (48%) | 50 (49%) |
| Mode of delivery | ||||||||
| Caesarean | 916 (43%) | 309 (52%) | 140 (36%) | 131 (39%) | 119 (37%) | 127 (43%) | 47 (43%) | 43 (42%) |
| Vaginal | 383 (18%) | 56 (9%) | 74 (19%) | 105 (31%) | 64 (20%) | 58 (19%) | 23 (21%) | 3 (3%) |
| Unknown | 855 (40%) | 226 (38%) | 179 (46%) | 99 (30%) | 141 (44%) | 113 (38%) | 40 (36%) | 57 (55%) |
| Preterm birth | ||||||||
| Full-term birth | 1652 (77%) | 421 (71%) | 297 (76%) | 270 (81%) | 258 (80%) | 248 (83%) | 78 (71%) | 80 (78%) |
| Preterm birth | 328 (15%) | 119 (20%) | 54 (14%) | 43 (13%) | 46 (14%) | 29 (10%) | 21 (19%) | 16 (16%) |
| Unknown | 174 (8%) | 51 (9%) | 42 (11%) | 22 (7%) | 20 (6%) | 21 (7%) | 11 (10%) | 7 (7%) |
*
Cause of death overall: HIV (n=53), SIDS (n=9), child abuse (n=3), others (n=16).
CWHchildren with HIVMoCHiVSwiss Mother and Child HIV Cohort StudySHCSSwiss HIV Cohort StudySIDSsudden infant death syndrome