Table 2. Baseline characteristics of CWH registered in MoCHiV between January 1986 and December 2022.
| Total | Zurich | Lausanne | Geneva | Basel | Bern | St. Gallen | Ticino | |
| CWH included in MoCHiV | ||||||||
| 285 | 81 | 47 | 52 | 37 | 37 | 16 | 15 | |
| Total infected children | ||||||||
| Active patients | 16 (6%) | 9 (11%) | 5 (11%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 2 (13%) |
| Transition to SHCS | 113 (40%) | 29 (36%) | 17 (36%) | 21 (40%) | 18 (49%) | 18 (49%) | 8 (50%) | 2 (13%) |
| Voluntary discontinuation | 15 (5%) | 6 (7%) | 2 (4%) | 4 (8%) | 2 (5%) | 1 (3%) | 0 (0%) | 0 (0%) |
| Died* | 61 (21%) | 23 (28%) | 10 (21%) | 7 (13%) | 6 (16%) | 5 (14%) | 2 (12%) | 8 (53%) |
| Lost to follow-up | 80 (28%) | 14 (17%) | 13 (28%) | 20 (38%) | 11 (30%) | 13 (35%) | 6 (38%) | 3 (20%) |
| Participation of mother in SHCS | ||||||||
| No participation | 187 (66%) | 56 (69%) | 32 (68%) | 31 (60%) | 27 (73%) | 23 (62%) | 6 (38%) | 12 (80%) |
| Participation | 98 (34%) | 25 (31%) | 15 (32%) | 21 (40%) | 10 (27%) | 14 (38%) | 10 (62%) | 3 (20%) |
| Age of inclusion | ||||||||
| At birth | 75 (26%) | 20 (25%) | 11 (23%) | 15 (29%) | 12 (32%) | 4 (11%) | 4 (25%) | 9 (60%) |
| Later | 210 (74%) | 61 (75%) | 36 (77%) | 37 (71%) | 25 (68%) | 33 (89%) | 12 (75%) | 6 (40%) |
| Median age at inclusion if later (IQR) | 3.8 (1.2–8.2) | 2.5 (0.9–5.1) | 5.6 (2.1–10.6) | 5.9 (3.5–10.6) | 4 (0.9–10) | 3.4 (1.6–6.3) | 4.2 (1.2–6.3) | 2 (0.8–3) |
| Sex | ||||||||
| Female | 150 (53%) | 42 (52%) | 25 (53%) | 29 (56%) | 21 (57%) | 16 (43%) | 7 (44%) | 10 (67%) |
| Male | 135 (47%) | 39 (48%) | 22 (47%) | 23 (44%) | 16 (43%) | 21 (57%) | 9 (56%) | 5 (33%) |
| Ethnicity | ||||||||
| White | 82 (29%) | 28 (35%) | 15 (32%) | 11 (21%) | 12 (32%) | 13 (35%) | 2 (12%) | 1 (7%) |
| Black | 74 (26%) | 9 (11%) | 14 (30%) | 21 (40%) | 15 (41%) | 7 (19%) | 6 (38%) | 2 (13%) |
| Hispano-American | 13 (5%) | 2 (2%) | 3 (6%) | 3 (6%) | 0 (0%) | 2 (5%) | 3 (19%) | 0 (0%) |
| Asian | 8 (3%) | 2 (2%) | 0 (0%) | 2 (4%) | 1 (3%) | 2 (5%) | 1 (6%) | 0 (0%) |
| Unknown | 108 (38%) | 40 (49%) | 15 (32%) | 15 (29%) | 9 (24%) | 13 (35%) | 4 (25%) | 12 (80%) |
| Source of HIV infection | ||||||||
| Vertical transmission | 217 (76%) | 59 (73%) | 37 (79%) | 47 (90%) | 24 (65%) | 29 (78%) | 12 (75%) | 9 (60%) |
| Blood products | 4 (1%) | 1 (1%) | 2 (4%) | 1 (2%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Heterosexual contact | 1 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 1 (3%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Unknown | 63 (22%) | 21 (26%) | 8 (17%) | 4 (8%) | 12 (32%) | 8 (22%) | 4 (25%) | 6 (40%) |
| Median follow-up time in years | ||||||||
| Median (IQR) | 8.3 (2.0–15) | 7.9 (1.5–16) | 6.9 (2.2–12) | 9.2 (2.6–15) | 9.4 (3.1–16) | 11 (5.8–15) | 4.1 (0–13) | 1.3 (0–10) |
*
Cause of death overall: HIV (n=53), SIDS (n=2), others (n=6).
CWHchildren with HIVMoCHiVSwiss Mother and Child HIV Cohort StudySHCSSwiss HIV Cohort StudySIDSsudden infant death syndrome