TABLE 1.

Pharmacokinetic parameters of unchanged form after a single oral or intravenous administration of 10 and 30 mg/kg RIF to male ICR mice and PXB mice.

	Dose	(mg/kg)	Oral		Intravenous
			10	30	10	30
ICR	C max	(ng/mL)	5417	17 367	—	—
	C 0.5 h	(ng/mL)	—	—	15 133	47 067
	T max	(h)	2.00	2.00	—	—
	AUC0‐last	(h·ng/mL)	40 124	164 672	98 842	498 982
	CLtot	(mL/h/kg)	—	—	100	59.8
	V d,ss	(mL/kg)	—	—	475	337
	t 1/2	(h)	3.96	3.64	3.74	3.11
PXB	C max	(ng/mL)	1277	4180	—	—
	C 0.5 h	(ng/mL)	—	—	1840	5903
	T max	(h)	2.33	0.83	—	—
	AUC0‐last	(h·ng/mL)	6593	25 898	7989	24 388
	CLtot	(mL/h/kg)	—	—	1169	1161
	V d,ss	(mL/kg)	—	—	2432	3404
	t 1/2	(h)	5.26	6.71	1.30	2.22

Abbreviations: AUC_0‐last, AUC from time zero to 8 h (intravenous administration in PXB mice) and time zero to 24 h (others); —, not applicable.