TABLE 2.

Estimated unbound RIF concentrations inlet to the liver and in systemic plasma in ICR and PXB mice at doses of 10 and 30 mg/kg.

	Dose (mg/kg)	Concentration (μmol/mL)
		I in,max,u	Maximum observed systemic unbound in plasma
ICR
p.o.	10	0.26	0.22
	30	0.82	0.70
i.v.	10	—	0.66
	30	—	1.91
PXB
p.o.	10	1.01	0.30
	30	3.10	0.97
i.v.	10	—	0.56
	30	—	1.43

Note: Data are expressed as mean (n = 3).