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Deng et al. found that chronic sleep fragmentation of 30 days significantly suppressed glymphatic influx, which was mirrored by cognitive decline. In vivo two-photon imaging in the awake state revealed that slow vasomotion rather than cardiac driven pulsations was suppressed in chronic sleep fragmented mice. Therefore, vascular dysfunction induced by sleep disturbance might impair brain metabolic waste clearance and increase the risk of developing dementia.
